Goal: The lifetime danger of creating a diabetic foot ulcer (DFU) in folks with diabetes is as excessive as 25%. A trio of things represent the diabetic foot syndrome that characterises DFUs, together with neuropathy, vascular illness and infections. Vitamin C has vital features within the nervous, cardiovascular, and immune programs which can be implicated in DFU improvement. Moreover, vitamin C deficiency has been noticed in people with DFUs, suggesting an vital perform of vitamin C in DFU administration and remedy. Subsequently, this literature evaluate evaluates the position of vitamin C within the nervous, cardiovascular and immune programs in relation to wound therapeutic and DFUs, in addition to discussing vitamin C’s lesser identified position in melancholy, a situation that impacts many people with a DFU.
Methodology: A literature search was accomplished utilizing PubMed, Cochrane Library, Embase, Ovid, Pc Retrieval of Data on Scientific Tasks, and NIH Medical Heart. Search phrases included ‘diabetic foot ulcer,’ ‘diabetic foot,’ ‘vitamin C,’ and ‘ascorbic acid.’
Outcomes: Of the 71 research initially recognized, seven research met the inclusion standards, and solely three have been human scientific trials. Total, the literature on this topic is proscribed, with primarily observational and animal research, and few human scientific trials.
Conclusion: There’s a want for extra human scientific trials on vitamin C supplementation in people with a DFU to fill the information hole and information scientific observe.
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